Partly Cloudy
0°CFri :Sunny. High: 2 Low: -6

Anti-diabetic substance discovered in liquorice root

Anti-diabetic substance discovered in liquorice root

Washington: Researchers have found promising anti-diabetic substance in the amorfrutin class of natural substances.

It provides the raw material for liquorice candy, calms the stomach and alleviates diseases of the airways: liquorice root.

Chosen as the “Medicinal plant 2012”, the root has been treasured in traditional healing since ancient times.

Researchers at the Max Planck Institute for Molecular Genetics in Berlin have now discovered that liquorice root also contains substances with an anti-diabetic effect.

These amorfrutins not only reduce blood sugar, they are also anti-inflammatory and are very well tolerated. Thus, they may be suitable for use in the treatment of complex metabolic disorders.

Natural substances have a surprising and often largely unexploited potential in the prevention and treatment of common diseases.

For example, liquorice root Glycyrrhiza contains different substances that help to alleviate disorders of the airways and digestive system. It has been used for millennia in traditional healing and is mainly administered in the form of tea.

A team of researchers working with Sascha Sauer from the Max Planck Institute for Molecular Genetics in Berlin has now discovered that the plant from the papilionaceae or leguminous family might also be effective in the treatment of adult (type 2) diabetes.

The scientists identified a group of natural substances with an anti-diabetic effect, the amorfrutins, in the plant’s edible root.

The substances, which have a simple chemical structure, are not only found in liquorice root, but are also in the fruit of the Amorpha fruticosa bush. The new anti-diabetic agents were named after this plant, which is native to the US, Canada and Mexico.

As the researchers demonstrated using diabetic mice, the amorfrutins not only have characteristics that reduce blood sugar, they are also anti-inflammatory in their effect. Moreover, they also prevent fatty liver – a common disease caused by excessively fat-rich nutrition.

“The health-beneficial effects are based on the fact that the amorfrutin molecules dock directly onto a receptor in the nucleus called PPAR (gamma),” explained Sascha Sauer.

PPAR (gamma) plays an important role in the cell’s fat and glucose metabolism.

The binding of the amorfrutin molecules activates various genes that reduce the plasma concentration of certain fatty acids and glucose. The reduced glucose level prevents the development of insulin resistance – the main cause of adult diabetes.

“Although there are already drugs on the market that affect the PPAR (gamma) receptor, they are not selective enough in their effect and cause side effects like weight gain and cardio-vascular problems,” said Sascha Sauer.

In contrast, as demonstrated by the studies carried out to date, the amorfrutins are very well tolerated.

“However, drinking liquorice tea or eating liquorice will not help to treat diabetes,” explained the scientist.

“The concentration of the substances in the tea and liquorice is far too low to be effective,” Sauer added.

The researchers therefore developed special extraction processes to obtain the amorfrutins from the plant in sufficient concentrations. This could be used to produce amorfrutin extracts on an industrial scale.

The newly discovered active substances not only seem to hold great promise for the treatment of complex metabolic disorders, they may also be suitable for prophylactic use.

 

Top Stories

IV_34_1

Sania Mirza may play IPTL singles

November-21-2014
Mumbai: After a completely remunerating year where she won her lady World Tour Finals to add to her US Open blended pairs
happyending

Happy Ending Movie Review

November-21-2014
It is never an especially decent thought to wed a Happy Ending to a rash of remaining details, however the come about
anushka

Kohli affirms relationship with Anushka

November-21-2014
Kohli said it was at that point clear that he and Anushka were seeing someone individuals ought not be interested about them
285653-red-beacon

SP leaders grumble against utilization of red signal by Congress MLA

November-21-2014
A gathering of nearby Samajawadi Party pioneers on Thursday submitted a grievance letter with the police against Congress pioneer and Mathura MLA
jaitley_hnd1

Jaitley Tells Bankers to act Professionally

November-21-2014
NEW DELHI: Finance Minister Arun Jaitley on Thursday met heads of open segment banks to talk about approaches to cut down climbing
Ranjit Sinha_CBI_PTI

2G Scam: Former CBI chiefs take a stand in opposition to Ranjit Sinha

November-21-2014
NEW DELHI: Even as CBI executive Ranjit Sinha asserted on Thursday that he didn’t name any officer as “mole” and that he