Partly Cloudy
-9°CThu :PM Showers. High: 3 Low: 0

Bat Plant shows cancer-fighting potential

Bat Plant shows cancer-fighting potential

Washington: Bat plant, or Tacca chantrieri, could be used to fight cancer, according to researchers with The University of Texas Health Science Center at San Antonio.

The researchers have pinpointed the cancer-fighting potential in the plant.

Susan Mooberry, Ph.D., leader of the Experimental Development Therapeutics Program at the Cancer Therapy and Research Center and a professor of pharmacology in the School of Medicine at the UT Health Science Center, has been working to isolate substances in the plant, looking for a plant-derived cancer drug with the potential of Taxol.

Taxol, the first microtubule stabilizer derived from the Yew family, has been an effective chemotherapy drug, but patients eventually develop problems with resistance over time and toxicity at higher doses.

So, researchers have long been seeking alternatives.

“We’ve been working with these for years with some good results, but never with the potency of Taxol,” said Dr. Mooberry, lead author of the study.

“Now we have that potency, and we also show for the first time the taccalonolides’ cellular binding site,” she stated.

Microtubules are structures in the cells that act as conveyer belts. They help maintain cell shape and help guide chromosones in cell division to ensure that every new cell, including every new cancer cell, gets a full complement of genetic material.

When microtubules are stabilized — essentially held still so they can’t do their jobs — this disrupts numerous cellular processes, and the cell can die.

The taccalonolides stabilize microtubules in cancer cells, but they do not attack healthy cells, Dr. Mooberry said.

“We’ve run normal prostate cells and normal breast cells through these tests, and they don’t die. The taccalonolides selectively kill cancer cells,” she noted.

 

Top Stories

gautam-gulati-karishma-tanna

‘Bigg Boss 8′ Voting Trend: Gautam Gulati, Karishma Tanna Leading for the time being; Pritam Singh Lagging Behind

January-29-2015
Uncovering the voting pattern, “Bigg Boss Live News” composed on Twitter that Gautam Gulati and Karishma Tanna are driving with greatest votes,
UP_Assembly_747902f

2 MLA’s excluded from UP Assembly after Lokayukta test

January-29-2015
LUCKNOW: Uttar Pradesh Mlas Bajrang Bahadur Singh of BJP and BSP’s Uma Shankar Singh were excluded by the Governor from state Assembly
maharashtra-government-plans-revamp-of-mumbai-chawls

Maharashtra government arrangements patch up of Mumbai chawls

January-29-2015
MUMBAI: In an offer to give better way of life to individuals living in chawls of Mumbai, Maharashtra government is wanting to
46052816.cms

Modi tightens hold over remote arrangement; BJP, Cong lock horns over Sujatha sacking

January-29-2015
NEW DELHI: Prime Minister Narendra Modi on Thursday let go India’s most elevated positioning ambassador and supplanted her with India’s minister to
Microsoft Corp Chief Executive Satya Nadella speaks at his first annual shareholders' meeting in Bellevue, Washington

Microsoft doles out more Office programming to draw in versatile clients

January-29-2015
Microsoft Corp made its mainstream Word, Excel and Powerpoint applications accessible for nothing on Android tablets on Thursday, denoting the most recent
305784-dhoni1

MS Dhoni emphazises on winning ‘each and every amusement’; needs to distinguish ‘best playing eleven’ before World Cup

January-29-2015
India, who have been not able to enroll a solitary win in the three Odis as such, were fortunate to get two