Partly Cloudy
26°CSat :Mostly Clear. High: 27 Low: 14

Bat Plant shows cancer-fighting potential

Bat Plant shows cancer-fighting potential

Washington: Bat plant, or Tacca chantrieri, could be used to fight cancer, according to researchers with The University of Texas Health Science Center at San Antonio.

The researchers have pinpointed the cancer-fighting potential in the plant.

Susan Mooberry, Ph.D., leader of the Experimental Development Therapeutics Program at the Cancer Therapy and Research Center and a professor of pharmacology in the School of Medicine at the UT Health Science Center, has been working to isolate substances in the plant, looking for a plant-derived cancer drug with the potential of Taxol.

Taxol, the first microtubule stabilizer derived from the Yew family, has been an effective chemotherapy drug, but patients eventually develop problems with resistance over time and toxicity at higher doses.

So, researchers have long been seeking alternatives.

“We’ve been working with these for years with some good results, but never with the potency of Taxol,” said Dr. Mooberry, lead author of the study.

“Now we have that potency, and we also show for the first time the taccalonolides’ cellular binding site,” she stated.

Microtubules are structures in the cells that act as conveyer belts. They help maintain cell shape and help guide chromosones in cell division to ensure that every new cell, including every new cancer cell, gets a full complement of genetic material.

When microtubules are stabilized — essentially held still so they can’t do their jobs — this disrupts numerous cellular processes, and the cell can die.

The taccalonolides stabilize microtubules in cancer cells, but they do not attack healthy cells, Dr. Mooberry said.

“We’ve run normal prostate cells and normal breast cells through these tests, and they don’t die. The taccalonolides selectively kill cancer cells,” she noted.

 

Top Stories

10536-2808-140918-iPhone_6_Plus-Teardown-l

Initially iphone 6 & iphone 6 Plus teardowns uncover high-limit batteries, modified innards

September-19-2014
Nearing hours after Apple dispatched the iphone 6 and 6 Plus on Friday, repair firms and sites are as of now performing
Untitled-5 copy-163781

Last rundown of Bigg Boss 8 candidates uncovered

September-19-2014
Mumbai: The most famous reality TV show ‘Bigg Boss 8′, facilitated by none however the widely adored Salman Khan will go on
hope-whosoever-comes-to-power-will-manage-country-well-says-indra-nooyi_111113095932

Fortune positions Indra Nooyi third most capable ladies ready to go

September-19-2014
New York: Pepsico’s India-conceived CEO Indra Nooyi has been positioned third most compelling businessperson by Fortune, the main Indian-beginning lady on the
Uddhav_Modi_AP_360

Shiv Sena Warns BJP on Seat-Sharing, Says ‘We Are Not Asking, We Are Giving’

September-19-2014
In the round of brinksmanship that the accomplices of 25 years are playing over seat-imparting for the Maharashtra races, the Shiv Sena
980189ac-ecf3-452c-b7a0-3bdc4f505fcdWallpAutoWallpaper2

Movie Review: Fawad Khan, Kirron Kher attempt yet neglect to spare Khoobsurat

September-19-2014
Sonam Kapoor’s Khoobsurat offering Fawad Khan inverse her, hits theaters on Friday. Touted as a redo of Hrishikesh Mukerhjee’s Khoobsurat (1980), the
children

Fighting Parents Can Hurt Emotional Growth of Children

September-18-2014
Wrangling parents put the enthusiastic development of their youngsters in peril, as indicated by another research by New York University. Conjugal issues