Partly Cloudy
23°CFri :Mostly Sunny. High: 29 Low: 18

Bitter gourd juice destroys pancreatic cancer cells

Bitter gourd juice destroys pancreatic cancer cells

Los Angeles: In a finding that could provide a new tool in cancer therapy, researchers have shown that the juice of bitter gourd (karela) effectively kills pancreatic cancer cells.

A University of Colorado cancer study published this week in the journal Carcinogenesis shows that bitter gourd juice restricts the ability of pancreatic cancer cells to metabolise glucose, thus cutting the cells` energy source and eventually killing them.

“Three years ago, researchers showed the effect of bitter gourd extract on breast cancer cells only in a petri dish. This study goes much, much farther. We used the juice — people especially in Asian countries are already consuming it in quantity. We show that it affects the glucose metabolism pathway to restrict energy and kill pancreatic cancer cells,” says Rajesh Agarwal, PhD, co-programme leader of Cancer Prevention and Control at the CU Cancer Center and professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences.

Diabetes tends to presage pancreatic cancer and bitter gourd has been shown to control type-II diabetes, and has been used for centuries against diabetes in the folk medicines of China and India.

Following this line of thinking, Agarwal and colleagues wondered what would happen if they closed out the middle man of diabetes and directly explored the link between bitter gourd and pancreatic cancer, reports Science Daily.

The result, Agarwal says, is, “alteration in metabolic events in pancreatic cancer cells and an activation of the AMP-activated protein kinase, an enzyme that indicates low energy levels in the cells”.

Perhaps not coincidentally, bitter gourd also regulates insulin secretion by pancreatic beta cells. After studies in cell cultures, the group showed that mouse models of pancreatic cancer that were fed bitter melon juice were 60 percent less likely to develop the disease than controls.

“It`s a very exciting finding,” Agarwal says. “Many researchers are engineering new drugs to target cancer cells` ability to supply themselves with energy, and here we have a naturally-occurring compound that may do just that.”

 

Top Stories

pioneer-624x351.png

Pioneer launches AVIC-F60BT premium in-car navigation and entertainment system

July-25-2014
In-car entertainment systems company Pioneer has launched its premium audio-video system, the Pioneer AVIC-F60BT, in India. Pioneer, which has already promised to
INSRANCE_THINKSTOCK-624x416

49% FDI in insurance: What it means for customers

July-25-2014
The Cabinet’s approval to increase the FDI limit in the insurance sector to 49 percent is expected to benefit the companies first
images

Businessman buys Rajesh Khanna’s bungalow ‘Aashirwad’ for Rs 90 crore

July-25-2014
MUMBAI: Bollywood superstar Rajesh Khanna’s Carter Road bungalow, popularly known as ‘Aashirwad’, is being sold to a city industrialist. The landmark sea-facing
Kick-Review-650

‘Kick’ review: Strictly for Salman Khan fans

July-25-2014
When Sajid Nadiadwala decided to step into the director`s shoes, he pulled all stops. He has invested everything he could to make
sanjita-gold-740

Commonwealth Games: Lifters Sukhen, Sanjita win gold as India make rousing start

July-25-2014
Glasgow: Sukhen Dey and K Sanjita Chanu stole the limelight by clinching a gold each in weightlifting, as India launched their campaign
M_Id_477210_FM_Arun_Jaitley

India will not have to wait for bringing back black money: Jaitley

July-25-2014
Finance Minister Arun Jaitley today said that India will not have to wait for long for bringing back the black money. He