Cloudy
-3°CFri :Cloudy. High: 3 Low: -3

Cannabis may help reduce spasticity

Cannabis may help reduce spasticity

Washington: Smoked cannabis may be an effective treatment for spasticity – a common and disabling symptom of multiple sclerosis (MS), a clinical study has found.

The placebo-controlled trial conducted on 30 adult MS patients at the University of California, San Diego School of Medicine, also resulted in reduced perception of pain, although participants also reported short-term, adverse cognitive effects and increased fatigue.

Principal investigator Jody Corey-Bloom, MD, PhD, professor of neurosciences and director of the Multiple Sclerosis Center at UC San Diego, and colleagues randomly assigned participants to either the intervention group (which smoked cannabis once daily for three days) or the control group (which smoked identical placebo cigarettes, also once a day for three days). After an 11-day interval, the participants crossed over to the other group.

“We found that smoked cannabis was superior to placebo in reducing symptoms and pain in patients with treatment-resistant spasticity, or excessive muscle contractions,” said Corey-Bloom.

Earlier reports suggested that the active compounds of medical marijuana were potentially effective in treating neurologic conditions, but most studies focused on orally administered cannabinoids. There were also anecdotal reports of MS patients that endorsed smoking marijuana to relieve symptoms of spasticity.

However, this trial used a more objective measurement, a modified Ashford scale that graded the intensity of muscle tone by measuring such things as resistance in range of motion and rigidity. The secondary outcome, pain, was measured using a visual analogue scale.

The researchers also looked at physical performance (using a timed walk) and cognitive function and – at the end of each visit – asked patients to assess their feeling of “highness.”

Although generally well tolerated, smoking cannabis did have mild effects on attention and concentration. The researchers noted that larger, long-terms studies are needed to confirm their findings and determine whether lower doses can result in beneficial effects with less cognitive impact.

The current study is the fifth clinical test of the possible efficacy of cannabis for clinical use reported by the University of California Center for Medicinal Cannabis Research (CMCR). Four other human studies on control of neuropathic pain also reported positive results.

“The study by Corey Bloom and her colleagues adds to a growing body of evidence that cannabis has therapeutic value for selected indications, and may be an adjunct or alternative for patients whose spasticity or pain is not optimally managed,” said Igor Grant, MD, director of the CMCR, which provided funding for the study.

 

Top Stories

bmw

BMW M3 and M4 Coupe propelled in India, estimated at Rs 1.20 cr, Rs 1.22 cr individually

November-28-2014
BMW has propelled the M3 car and M4 Coupe execution twins in India with costs beginning at Rs 1.20 crore (M3 car)
Micromax-Canvas-Tab-P666-Photo-1-765x387

Micromax dispatches Intel based Canvas Tab P666 in India for Rs 10999

November-28-2014
Micromax, on Thursday propelled its new tablet Canvas Tab P666 in the Indian market for Rs. 10,999. Micromax has banded together with
Amit_Shah_650_rally_generic_20Nov14_1

For Amit Shah’s Kolkata Rally, BJP’s ‘Guinness Record’

November-28-2014
KOLKATA – A battle over Amit Shah’s rally in Kolkata on Sunday has driven the BJP to court the third time in
power-minister-piyush-goyal-says-government-will-act-soon-to-resolve-fuel-issue

Power Minister Piyush Goyal says government will act soon to intention fuel lack issue

November-28-2014
MUMBAI: India’s fuel-starved force undertakings would have the capacity to give a reward 30,000 MW ability to fuel the normal surge in
Srini_gurunath_LalitModi

IPL spot-altering: SC ought to rebuff Srinivasan, Meiyappan not scrap CSK

November-28-2014
We have to be mindful so as not to toss the child out with the bathwater. For all its apparent ills, the
ungli-zid-759

Emraan Hashmi, Randeep Hooda’s ‘Ungli’, Mannara’s “Zid” release today

November-28-2014
We have three exceptionally fascinating movies discharging this Friday – multi-starrer ‘Ungli’, Priyanka Chopra’s cousin Mannara’s introduction film, “Zid” and Adil Hussain’s