Light Rain
1°CMon :Light Rain. High: 2 Low: 0

Drug from Foxgloves could treat breast cancer

Drug from Foxgloves could treat breast cancer

London: Drug extracted from one of Britain’s most popular flowers ‘Foxgloves’ could soon be used as treatment to stop spread of breast cancer, a new study has suggested.

Scientists in the U.S. have revealed that digoxin, a long-established drug based on chemicals found in foxglove, can block the production of a protein called HIF-1, which has been held responsible for the spread of breast cancer.

Digoxin has been used for decades to treat conditions like congestive heart failure and irregular heartbeats and the latest discovery, by a team at Johns Hopkins University in Baltimore, USA, has suggested that this cheap and easily available medicine could also be used in the fight against cancer.

“This is really exciting,” the Daily Mail quoted research leader Dr Gregg Semenza, from the Institute for Cell Engineering at the university as saying.

“Our findings warrant clinical trials to determine if the doses (used in animal studies) are enough to sufficiently block HIF-1 and slow breast cancer growth and spread.”

To see how the HIF-1 protein behaved when exposed to digoxin, researchers transplanted human breast cancer cells into mice and, two weeks later, gave them daily injections of either the drug itself or saline.

The study revealed that those who were given digoxin had fewer cancer cells spread to the lungs – one of the major sites that breast tumours migrate to – and tumours that had spread were smaller than in the saline group.

The findings could be even more significant because the research team found evidence that cancer cells start to spread from the breast to the lung much before than was previously thought.

This could indicate that if further trials verify the benefits of the drug, it is possible it could be routinely used in women with aggressive tumours to try and reduce the risk of them spreading.

Dr Caitlin Palframan, from Breakthrough Breast Cancer, insisted that the research is still in its early stages and clinical trials are needed to see if the drug can slow breast cancer growth and spread in humans.

“However, it is exciting as digoxin has been used for decades in medical treatment with a proven safety record.”

“We hope it means clinical trials will move quickly, allowing us to learn more about whether this approach will work to help prolong lives,” Dr Palframan added.

 

Top Stories

diandra-gautam-759

I was scarred: Gautam Gulati on his ‘special friendship’ with Diandra Soares

December-22-2014
‘Bigg Boss 8′ member Gautam Gulati, who did not recognize his association with individual expelled contender Diandra Soares notwithstanding imparting at home
govt-seeks-parliaments-approval-for-additional-rs-7500-crore-spending_230813013111

Conversion issue rocks Parliament once again

December-22-2014
NEW DELHI: The Union government does not help change or re-transformation, parliamentary undertakings pastor M Venkaiah Naidu told the Lok Sabha on
2611-mumbai-terror-attacks-trial-in-pakistan-adjourned-till-june-11_050614050926

In spite of former insights inputs, India, US, Britain neglected to keep the 26/11 Mumbai dread assault

December-22-2014
India, USA and Britain had been following the exercises of Lashkar-e-Toiba terrorists behind the 26/11 Mumbai assaults before they went on frenzy
PK-Movie-Aamir-Khan-and-Anushka-Sharma-New-Poster-Images

Aamir Khan’s PK Makes Over Rs 90 Crores in First Weekend

December-22-2014
PK had a staggering Sunday, reports Box Office India, which puts the day’s profit at Rs 37 crores Aamir Khan’s new motion
yureka_registration_amazon

Micromax’s Yu Yureka Off to a Rocky Start; Launch Date Revealed

December-22-2014
Micromax’s new Yu brand of cell phones is set for a rough begin notwithstanding a dispatch that quieted commentators of the organization.
1411984543-6614

Sensex surges 100 points…nifty over 8,250 levels

December-22-2014
At 2:29pm, the S&p BSE Sensex is exchanging at 27,497 up 125 focuses, while NSE Nifty is exchanging at 8,262 up 37