Partly Cloudy
24°CSat :Partly Cloudy. High: 29 Low: 22

Dye from lichens may help combat Alzheimer’s

Dye from lichens may help combat Alzheimer’s

Washington: A red coloured dye derived from Lichens, which has been used for centuries to colour fabrics and food, may help to reduce the abundance of small toxic protein aggregates in Alzheimer’s disease, a new study has claimed.

The dye, a compound called orcein, and a related substance, called O4, bind preferentially to small amyloid aggregates that are considered to be toxic and cause neuronal dysfunction and memory impairment in Alzheimer’s disease.

O4 binding to small aggregates promotes their conversion into large, mature plaques which researchers assume to be largely non-toxic for neuronal cells.

Protein misfolding is considered to be the cause of Alzheimer’s, Parkinson’s and also Huntington’s disease. In a multistep process, proteins misfold and accumulate into large extra- or intracellular plaques.

Erich Wanker and his team of researchers from Berlin assume that small misfolded protein aggregates that are precursors of mature plaques are toxic for nerve cells and are the reason why they are eventually destroyed.

The synthetic dye methylene blue is currently being tested in clinical trials. This dye also seems to stimulate the formation of large plaques in a way similar to O4. Other therapeutic approaches tested in clinical trials which aim at eliminating small precursor aggregates have so far not led to a significant improvement of disease symptoms.

However, it still remains to be seen whether the blue dye O4 can also be effective against small amounts of misfolded proteins in the brains of Alzheimer’s patients and whether the accelerated formation of larger plaques can indeed reduce the signs and symptoms of Alzheimer’s disease in humans.

“We hope that our findings will stimulate research activities in this direction, especially in drug discovery,” Wanker said.

 

Top Stories

cbi-2

CBI strikes living arrangement of MLA’s and former cops regarding Saradha trick

August-29-2014
GUWAHATI: The CBI on Thursday did look operations in a few prominent areas in Guwahati regarding multi crore Saradha trick. Sources said
Pankaja-Munde

Munde’s little girl Pankaja says Don’t politicize my father’s demise

August-29-2014
Sindkhed Raja: Former Union Minister Gopinath Munde’s little girl Pankaja Munde today propelled a “Sangharsh Yatra,” asking her depreciators not to politicize
35315852.cms

Modi delights in double the security spread of his forerunner

August-29-2014
New Delhi: Prime Minister Narendra Modi delights in twofold the security spread of his forerunner Manmohan Singh regarding commandos of the tip
Malaysia-Airlines

Malaysia Airlines to cut 6,000 staff in upgrade

August-29-2014
Travelers are prepared to weigh in at a takeoff anteroom at Kuala Lumpur International Airport in Sepang, Malaysia, Friday, Aug. 29, 2014.
wwq

Bigg Boss going to be much more hotter than before : Expected Contestants List

August-28-2014
All Bigg Boss 8 fans are excitedly sitting tight for the Bigg Boss 8 Contestants? How about we go to swing in
Inside Gold Bars Refining Plant As Gold Declines

Gold, silver bounce back on global cues, regular interest

August-28-2014
Gold costs recuperated by Rs. 55 to close at Rs. 28,230 for every ten gram in the national capital on Thursday, generally