Mostly Cloudy
12°CWed :Partly Cloudy. High: 15 Low: 8

Dye from lichens may help combat Alzheimer’s

Dye from lichens may help combat Alzheimer’s

Washington: A red coloured dye derived from Lichens, which has been used for centuries to colour fabrics and food, may help to reduce the abundance of small toxic protein aggregates in Alzheimer’s disease, a new study has claimed.

The dye, a compound called orcein, and a related substance, called O4, bind preferentially to small amyloid aggregates that are considered to be toxic and cause neuronal dysfunction and memory impairment in Alzheimer’s disease.

O4 binding to small aggregates promotes their conversion into large, mature plaques which researchers assume to be largely non-toxic for neuronal cells.

Protein misfolding is considered to be the cause of Alzheimer’s, Parkinson’s and also Huntington’s disease. In a multistep process, proteins misfold and accumulate into large extra- or intracellular plaques.

Erich Wanker and his team of researchers from Berlin assume that small misfolded protein aggregates that are precursors of mature plaques are toxic for nerve cells and are the reason why they are eventually destroyed.

The synthetic dye methylene blue is currently being tested in clinical trials. This dye also seems to stimulate the formation of large plaques in a way similar to O4. Other therapeutic approaches tested in clinical trials which aim at eliminating small precursor aggregates have so far not led to a significant improvement of disease symptoms.

However, it still remains to be seen whether the blue dye O4 can also be effective against small amounts of misfolded proteins in the brains of Alzheimer’s patients and whether the accelerated formation of larger plaques can indeed reduce the signs and symptoms of Alzheimer’s disease in humans.

“We hope that our findings will stimulate research activities in this direction, especially in drug discovery,” Wanker said.

 

Top Stories

bjp-lost-17-seats-in-haryana-by-a-narrow-margin

BJP lost 17 seats in Haryana by a thin edge

October-22-2014
NEW DELHI: The BJP’s triumph in Haryana can’t simply be surveyed through the quantity of seats the gathering won additionally by the
44895643.cms

Sunny Leone’s Special Birthday surprise For Husband Daniel Weber

October-21-2014
Sunny Leone had masterminded an unique birthday festival for her spouse Daniel Weber in Thailand. A couple of days prior, Daniel had
IndiaTv1611f0_cfc

ISL mentors among a few peering toward India work

October-21-2014
PANAJI: There is life past the commotion and fervor of the Indian Super group, particularly for the mentors on obligation. Most mentors
06-rupee6

Rupee picks up 8 paise against dollar in early trade

October-21-2014
MUMBAI: Extending its climbing streak for the third straight day, the rupee increased in value by 8 paise to 61.28 against the
IndiaTv568462_akhilesh

Akhilesh Yadav the CM of UP gets feel of power crisis

October-21-2014
Lucknow: Uttar Pradesh Chief Minister Akhilesh Yadav and his bureau got a direct knowledge of the dismal force situation in the state
BJP flag

Maharashtra: Congress hits once more at NCP, says will never help Shiv Sena

October-21-2014
New Delhi: Senior Congress pioneer Ajay Maken hit over at National Congress Party boss Sharad Pawar by saying that the gathering will