Cloudy
12°CSun :Rain. High: 12 Low: 9

Dye from lichens may help combat Alzheimer’s

Dye from lichens may help combat Alzheimer’s

Washington: A red coloured dye derived from Lichens, which has been used for centuries to colour fabrics and food, may help to reduce the abundance of small toxic protein aggregates in Alzheimer’s disease, a new study has claimed.

The dye, a compound called orcein, and a related substance, called O4, bind preferentially to small amyloid aggregates that are considered to be toxic and cause neuronal dysfunction and memory impairment in Alzheimer’s disease.

O4 binding to small aggregates promotes their conversion into large, mature plaques which researchers assume to be largely non-toxic for neuronal cells.

Protein misfolding is considered to be the cause of Alzheimer’s, Parkinson’s and also Huntington’s disease. In a multistep process, proteins misfold and accumulate into large extra- or intracellular plaques.

Erich Wanker and his team of researchers from Berlin assume that small misfolded protein aggregates that are precursors of mature plaques are toxic for nerve cells and are the reason why they are eventually destroyed.

The synthetic dye methylene blue is currently being tested in clinical trials. This dye also seems to stimulate the formation of large plaques in a way similar to O4. Other therapeutic approaches tested in clinical trials which aim at eliminating small precursor aggregates have so far not led to a significant improvement of disease symptoms.

However, it still remains to be seen whether the blue dye O4 can also be effective against small amounts of misfolded proteins in the brains of Alzheimer’s patients and whether the accelerated formation of larger plaques can indeed reduce the signs and symptoms of Alzheimer’s disease in humans.

“We hope that our findings will stimulate research activities in this direction, especially in drug discovery,” Wanker said.

 

Top Stories

IV_34_1

Sania Mirza may play IPTL singles

November-21-2014
Mumbai: After a completely remunerating year where she won her lady World Tour Finals to add to her US Open blended pairs
happyending

Happy Ending Movie Review

November-21-2014
It is never an especially decent thought to wed a Happy Ending to a rash of remaining details, however the come about
anushka

Kohli affirms relationship with Anushka

November-21-2014
Kohli said it was at that point clear that he and Anushka were seeing someone individuals ought not be interested about them
285653-red-beacon

SP leaders grumble against utilization of red signal by Congress MLA

November-21-2014
A gathering of nearby Samajawadi Party pioneers on Thursday submitted a grievance letter with the police against Congress pioneer and Mathura MLA
jaitley_hnd1

Jaitley Tells Bankers to act Professionally

November-21-2014
NEW DELHI: Finance Minister Arun Jaitley on Thursday met heads of open segment banks to talk about approaches to cut down climbing
Ranjit Sinha_CBI_PTI

2G Scam: Former CBI chiefs take a stand in opposition to Ranjit Sinha

November-21-2014
NEW DELHI: Even as CBI executive Ranjit Sinha asserted on Thursday that he didn’t name any officer as “mole” and that he