Fair
7°CMon :Mostly Clear. High: 17 Low: 6

Dye from lichens may help combat Alzheimer’s

Dye from lichens may help combat Alzheimer’s

Washington: A red coloured dye derived from Lichens, which has been used for centuries to colour fabrics and food, may help to reduce the abundance of small toxic protein aggregates in Alzheimer’s disease, a new study has claimed.

The dye, a compound called orcein, and a related substance, called O4, bind preferentially to small amyloid aggregates that are considered to be toxic and cause neuronal dysfunction and memory impairment in Alzheimer’s disease.

O4 binding to small aggregates promotes their conversion into large, mature plaques which researchers assume to be largely non-toxic for neuronal cells.

Protein misfolding is considered to be the cause of Alzheimer’s, Parkinson’s and also Huntington’s disease. In a multistep process, proteins misfold and accumulate into large extra- or intracellular plaques.

Erich Wanker and his team of researchers from Berlin assume that small misfolded protein aggregates that are precursors of mature plaques are toxic for nerve cells and are the reason why they are eventually destroyed.

The synthetic dye methylene blue is currently being tested in clinical trials. This dye also seems to stimulate the formation of large plaques in a way similar to O4. Other therapeutic approaches tested in clinical trials which aim at eliminating small precursor aggregates have so far not led to a significant improvement of disease symptoms.

However, it still remains to be seen whether the blue dye O4 can also be effective against small amounts of misfolded proteins in the brains of Alzheimer’s patients and whether the accelerated formation of larger plaques can indeed reduce the signs and symptoms of Alzheimer’s disease in humans.

“We hope that our findings will stimulate research activities in this direction, especially in drug discovery,” Wanker said.

 

Top Stories

jaya_2337499f

SC clears remain focused HC giving judgment on Jayalalithaa’s allure in unbalanced resources case

April-27-2015
New Delhi: The Supreme Court emptied keep focused High Court giving decision on previous Tamil Nadu boss clergyman J Jayalalithaa’s allure in
350756-naidu26.04.15

Farmer’s Suicide Has Nothing to do with Land Bill: Venkaiah

April-27-2015
HYDERABAD:Union parliamentary issues clergyman M Venkaiah Naidu on Sunday made it pass that the suicide by Gajendra Singh, an agriculturist from Rajasthan,
airtel-logo

Airtel makes voice free for broadband clients

April-27-2015
Only couple of days after BSNL declared free night requires its landline supporters, Bharti Airtel has reported that beginning today its broadband
Atif-aslam

Atif Aslam goes the EDM way

April-27-2015
Well known Pakistani musical performer Atif Aslam gave his band a miss and collaborated with DJ Chetas to produce electronic move music
Pepsi IPL 2015 - M26 DD v RCB

IPL 8: Starc stars again as RCB mallet DD in 10-wicket win

April-27-2015
A sharp show of pace bowling by Royal Challengers Bangalore (RCB) helped them beat hosts Delhi Daredevils by 10 wickets in an
0

JAC Results 2015: Jharkhand Board (JAC) Class 10th, 12th Results prone to be declared today

April-27-2015
New Delhi: The sit tight for JAC Class 10th and Class 12th Results is prone to be over today when JAC Class