Fair
-1°CWed :Sunny. High: 11 Low: -1

Green tea holds promise against Alzheimer`s

Green tea holds promise against Alzheimer`s

Washington: Researchers at the University of Michigan have found that a molecule in green tea can prevent misfolding of specific proteins in the brain, which is associated with amyloid plaques in Alzheimer`s disease.

The aggregation of these proteins, called metal-associated amyloids, is also associated with other neurodegenerative conditions.

U-M Life Sciences Institute faculty member Mi Hee Lim and an interdisciplinary team of researchers used green tea extract to control the generation of metal-associated amyloid-beta aggregates associated with Alzheimer`s disease in the lab.

The specific molecule in green tea, epigallocatechin-3-gallate, also known as EGCG, prevented aggregate formation and broke down existing aggregate structures in the proteins that contained metals-specifically copper, iron and zinc.

“A lot of people are very excited about this molecule,” said Lim, noting that the EGCG and other flavonoids in natural products have long been established as powerful antioxidants.

“We used a multidisciplinary approach. This is the first example of structure-centric, multidisciplinary investigations by three principal investigators with three different areas of expertise,” the researcher added.

The research team included chemists, biochemists and biophysicists.

While many researchers are investigating small molecules and metal-associated amyloids, most are looking from a limited perspective, said Lim, assistant professor of chemistry and research assistant professor at the Life Sciences Institute, where her lab is located and her research is conducted.

“But we believe you have to have a lot of approaches working together, because the brain is very complex,” she said.

Lim and her team`s next step is to “tweak” the molecule and then test its ability to interfere with plaque formation in fruit flies.

“We want to modify them for the brain, specifically to interfere with the plaques associated with Alzheimer`s,” she said.

The study was published recently in the Proceedings of the National Academy of Sciences.

 

Top Stories

Post retirement, PM to move to bungalow vacated by Sheila Dikshit

Post retirement, PM to move to bungalow vacated by Sheila Dikshit

February-28-2014
New Delhi: A sprawling bungalow on Motilal Nehru Place will be the abode of Prime Minister Manmohan Singh once he retires after
Sukhbir Singh Badal takes jibe at Congress, dubs it as 'politically pauper'

Sukhbir Singh Badal takes jibe at Congress, dubs it as ‘politically pauper’

February-28-2014
Muktsar: Describing Congress as “politically pauper”, Punjab Deputy Chief Minister Sukhbir Singh Badal on Friday alleged that Congress was facing severe political
Train fires: Railways to reply SC on use of sub-standard materials

Train fires: Railways to reply SC on use of sub-standard materials

February-28-2014
New Delhi: The Supreme Court on Friday sought response from the Centre and Railways on the allegation that use of sub-standard materials
Dark matter annihilation may be possible

Dark matter annihilation may be possible

February-28-2014
Washington: Researchers have claimed that gamma-ray photons observed from the center of the Milky Way Galaxy are consistent with the intriguing possibility
INS Sindhuratna fire: Police register accidental death case

INS Sindhuratna fire: Police register accidental death case

February-28-2014
Mumbai: On Thursday, police registered a case of accidental death over the fire incident on board the submarine INS Sindhuratna, in which
Electric bus service debuts in Bangalore

Electric bus service debuts in Bangalore

February-28-2014
Bangalore: State-run Bangalore Metropolitan Transport Corporation (BMTC) Friday began operating an electrically-charged bus service to provide eco-friendly public transport to commuters. Initially,