Partly Cloudy
15°CWed :Mostly Clear. High: 23 Low: 13

Green tea holds promise against Alzheimer`s

Green tea holds promise against Alzheimer`s

Washington: Researchers at the University of Michigan have found that a molecule in green tea can prevent misfolding of specific proteins in the brain, which is associated with amyloid plaques in Alzheimer`s disease.

The aggregation of these proteins, called metal-associated amyloids, is also associated with other neurodegenerative conditions.

U-M Life Sciences Institute faculty member Mi Hee Lim and an interdisciplinary team of researchers used green tea extract to control the generation of metal-associated amyloid-beta aggregates associated with Alzheimer`s disease in the lab.

The specific molecule in green tea, epigallocatechin-3-gallate, also known as EGCG, prevented aggregate formation and broke down existing aggregate structures in the proteins that contained metals-specifically copper, iron and zinc.

“A lot of people are very excited about this molecule,” said Lim, noting that the EGCG and other flavonoids in natural products have long been established as powerful antioxidants.

“We used a multidisciplinary approach. This is the first example of structure-centric, multidisciplinary investigations by three principal investigators with three different areas of expertise,” the researcher added.

The research team included chemists, biochemists and biophysicists.

While many researchers are investigating small molecules and metal-associated amyloids, most are looking from a limited perspective, said Lim, assistant professor of chemistry and research assistant professor at the Life Sciences Institute, where her lab is located and her research is conducted.

“But we believe you have to have a lot of approaches working together, because the brain is very complex,” she said.

Lim and her team`s next step is to “tweak” the molecule and then test its ability to interfere with plaque formation in fruit flies.

“We want to modify them for the brain, specifically to interfere with the plaques associated with Alzheimer`s,” she said.

The study was published recently in the Proceedings of the National Academy of Sciences.

 

Top Stories

ms_windows10-624x351

Windows 10: A seak look at Microsoft’s most recent working framework

October-02-2014
Microsoft has reported its ‘Windows 10′ working framework to supplant the generally disagreeable Windows 8, skirting a number to stamp a jump
the-story-of-my-experiments-with-truth

Gandhi’s life autobiography to be introduce in Punjabi, Kashmiri

October-02-2014
Ahmedabad: Mahatma Gandhi’s life account ‘The Story of My Experiments with Truth’ has now been distributed in Kashmiri and Punjabi dialects likewise
jaya_verdict_docu_650

8 Big Quotes From Court Order That Declared Jayalalithaa Guilty

October-02-2014
J Jayalalithaa, a standout amongst the most influential and prominent legislators from Tamil Nadu, will use at any rate an alternate week
haider-vs-bang-bang_625x300_51412222201

Today’s Big Releases: Bang, Haider

October-02-2014
Both Haider and Bang incorporate gunfire, lies, affection and energy It’s a motion picture weekend fans have been holding up for a
18_4

Swachh Bharat Abhiyan: PM Narendra Modi to wield sweeper to give India another picture

October-02-2014
NEW DELHI: After just about a week-long cleanliness drive in focal government business locales headed by Cabinet priests, Prime Minister Narendra Modi
Tombstone

Orkut close down, clients asked to fare photographs

October-01-2014
BANGALORE: Google pulled the attachment of the once commended person to person communication site, Orkut, on September 30. Before Google wandered into