Mostly Cloudy
26°CTue :Partly Cloudy. High: 33 Low: 21

Milk thistle may help halt spread of lung cancers

Milk thistle may help halt spread of lung cancers

Washington: An Indian origin scientist has suggested that silibinin, a major component of milk thistle, may be a promising therapeutic compound in the treatment of lung cancer.

Alpna Tyagi, PhD, of the University of Colorado Skaggs School of Pharmacy, and her team found that treatment with silibinin stopped the spread of these lung cancers in mouse.

Tissue with wound-like conditions allows tumours to grow and spread.

In the new animal study, silibinin help removed the molecular billboards that signal these wound-like conditions inhibiting the spread of these lung cancers,

Though the natural extract has been used for more than 2,000 years, mostly to treat disorders of the liver and gallbladder, this is one of the first carefully controlled and reported studies to find benefit.

Basically, in a cell there can be a chain of signals, one leading to the next, to the next, and eventually to an end product.

The end products COX2 and iNOS are enzymes involved with the inflammatory response to perceived wounds – both can aid tumour growth.

Far upstream in the signalling chain that leads to these unwanted enzymes are STAT1 and STAT3. These transcription factors allow the blueprint of DNA to bind with proteins that continue the signal cascade, eventually leading to the production of harmful COX2 and iNOS.

Stop STAT1 and STAT3 and you break the chain that leads to COX2 and iNOS – and the growth of lung tumours along with them.

“This relatively nontoxic substance – a derivative of milk thistle, called silibinin – was able to inhibit the upstream signals that lead to the expression of COX2 and iNOS,” said Tyagi.

In addition, Tyagi and collaborators compared the effects of silibinin to drugs currently in clinical trials for lung cancer.

Compared to these multi-million dollar drugs, naturally occurring silibinin blocked not only the expression of COX2 and iNOS, but also the migration of existing lung cancer cells.

“What we showed is that STAT1 and STAT3 may be promising therapeutic targets in the treatment of lung cancer, no matter how you target them,” Tyagi stated.

“And also that naturally-derived products like silibinin may be as effective as today’s best treatments,” she added.

The study has been recently published in the journal Molecular Carcinogenesis.

 

Top Stories

pomegranate-628x363-TS-160590221

Five capable wellbeing profits of consuming pomegranate!

September-02-2014
Pomegranate (natural name is Punica granatum) is a tasty foods grown from the ground, as well as high in sustenance. Rich in
abhi-ash_650_090214050713

Hubby Bachchan convinced Aishwarya Rai to take up Jazbaa

September-02-2014
Guess who was behind Aishwarya Rai’s decision to sign an action-thriller as her comeback vehicle? Yes, it was none other than her
TCS_Logo_Reuters

TCS, HCL Tech, Mahindra among dozen Indian cos in Forbes Asia’s Fab 50 rundown

September-02-2014
New Delhi: twelve Indian organizations figure in the 2014 Forbes Asia’s Fabulous 50 rundown of the region’s'best enormous traded on an open
bull-bear-market-4_slide

Sensex crosses 27000 imprint, Nifty hit new high on bringing down present record shortage; Cipla most astounding gainer

September-02-2014
The BSE Sensex today climbed by 151 focuses to surpass the 27,000-imprint shockingly and Nifty hit the record 8,100-level on purchasing by
224573-enough

Indeed schools and courts ought to have against inappropriate behavior manages set up

September-02-2014
The 20-part panel headed by resigned Justice Chandrashekhar Dharmadhikari has suggested adherence to the Vishakha rules, framed to handle lewd behavior at
social_welfare_16-9_0111_356

‘Love Jihad’: Improbability & test of change

September-02-2014
Leaving aside some narrative occurrences of between public affection and transformations to Islam coming about because of these contacts, the truth of