Mostly Cloudy
22°CWed :Partly Cloudy. High: 23 Low: 14

Milk thistle may help halt spread of lung cancers

Milk thistle may help halt spread of lung cancers

Washington: An Indian origin scientist has suggested that silibinin, a major component of milk thistle, may be a promising therapeutic compound in the treatment of lung cancer.

Alpna Tyagi, PhD, of the University of Colorado Skaggs School of Pharmacy, and her team found that treatment with silibinin stopped the spread of these lung cancers in mouse.

Tissue with wound-like conditions allows tumours to grow and spread.

In the new animal study, silibinin help removed the molecular billboards that signal these wound-like conditions inhibiting the spread of these lung cancers,

Though the natural extract has been used for more than 2,000 years, mostly to treat disorders of the liver and gallbladder, this is one of the first carefully controlled and reported studies to find benefit.

Basically, in a cell there can be a chain of signals, one leading to the next, to the next, and eventually to an end product.

The end products COX2 and iNOS are enzymes involved with the inflammatory response to perceived wounds – both can aid tumour growth.

Far upstream in the signalling chain that leads to these unwanted enzymes are STAT1 and STAT3. These transcription factors allow the blueprint of DNA to bind with proteins that continue the signal cascade, eventually leading to the production of harmful COX2 and iNOS.

Stop STAT1 and STAT3 and you break the chain that leads to COX2 and iNOS – and the growth of lung tumours along with them.

“This relatively nontoxic substance – a derivative of milk thistle, called silibinin – was able to inhibit the upstream signals that lead to the expression of COX2 and iNOS,” said Tyagi.

In addition, Tyagi and collaborators compared the effects of silibinin to drugs currently in clinical trials for lung cancer.

Compared to these multi-million dollar drugs, naturally occurring silibinin blocked not only the expression of COX2 and iNOS, but also the migration of existing lung cancer cells.

“What we showed is that STAT1 and STAT3 may be promising therapeutic targets in the treatment of lung cancer, no matter how you target them,” Tyagi stated.

“And also that naturally-derived products like silibinin may be as effective as today’s best treatments,” she added.

The study has been recently published in the journal Molecular Carcinogenesis.

 

Top Stories

274043-bp-700

Main five tasty nourishments for bringing down blood pressure!

September-17-2014
Hypertension or hypertension is an unending medicinal condition in which the blood stream in the supply routes is regularly high. In the
Dhoni Gambhir_DC

Kolkata Knight Riders face previous Clt20 champions CSK in Hyderabad

September-17-2014
Hyderabad: Champions League T20 is to have a blockbuster opening as 2-time IPL champions, Kolkata Knight Riders (KKR) and mutiple time IPL
camtest1

BSNL publishes cost free data offers on Micromax cell phones

September-17-2014
Micromax and BSNL published a vital association to drive information development in the nation. Under this organization, Micromax and BSNL will amplify
53527

India’s entertainment and media industry to clock over Rs 227000 crore by 2018: CII-Pwc study

September-17-2014
Estimates CAGR of 15% somewhere around 2013 and 2018 India’s stimulation and media part is relied upon to develop consistently throughout the
IndiaTv6ecccf_Vrindavan-widow20159

Vrindavan widows ought to stay in individual states: Hema Malini

September-17-2014
Mathura: Bharatiya Janata Party’s Lok Sabha part from Mathura-Vrindavan, cine star Hema Malini has addressed the vicinity of widows from Bihar and
bjp-supporters-arrive-to-attend-bjp-prime-ministerial-candidate-and-gujarat-chief-minister-narendra-modi23

Amit Shah says “with Narendra Modi as PM, India’s believability crisis has finished”

September-17-2014
AHMEDABAD: BJP president Amit Shah today said that India’s “believability emergency” has finished under the authority of Prime Minister Narendra Modi and