Partly Cloudy
25°CSat :Mostly Clear. High: 30 Low: 21

Mushroom compound boosts cancer drug

Mushroom compound boosts cancer drug

Washington: A compound from a wild, poisonous mushroom growing in the southwestern China`s forests, imparts greater punch to a cancer-busting drug, new research shows.

The compound, verticillin A, sensitizes cancer cells to TRAIL, a drug, causing cancer cells to self-destruct, said Kebin Liu, cancer immunologist at the Georgia Health Sciences University Cancer Centre and study co-author.

The compound pre-empts cancer cells from developing resistance to TRAIL (tumor necrosis factor-related apoptosis inducing ligand), reports the journal Cancer Research.

Drug resistance, intrinsic or acquired, is a major problem for cancer patients, accounting for more than 90 percent of treatment failures. “If we can make drugs work again, more people will survive,” Liu said, according to a Georgia Health statement.

“It looks as though most cancer cells have found a way to become resistant and evade its action,” said Wendy Bollag, cell physiologist and Liu`s counterpart in the study. Tenacious cancer cells are also naturally resistant to cell suicide, which is how TRAIL works.

In mice, they found verticillin A alone was adequate to kill cancer cells, but the required dose made the mice sick, a common problem with many cancer therapies.

However, when a lower dose was paired with TRAIL, it became a powerful, more tolerable recipe that killed previously resistant cells.

 

Top Stories

Clipboas

UP launches mobile application for HIV awareness

July-11-2014
Lucknow: Uttar Pradesh has launched a phone application for iPhone and android users to create awareness about HIV/AIDS, an official said Friday.
3DTouch-new

Is It The End Of Mouse? Here Comes 3DTouch

July-11-2014
If there is anything that hasn’t changed in computers over the years, it has to the mouse. While there have been new
135e88ca-6fbc-47a7-b0ba-0e9197ca12d0MediumRes

India vs England: Shami stars as India take charge of first Test

July-11-2014
Ominously, it was almost a repeat of the script for England. India had started and finished Wednesday strongly to take the upper
HUMPTY_POSTER

Movie review: Alia and Varun’s Humpty Sharma Ki Dulhaniya is a fun-filled ride

July-11-2014
Movie: Humpty Sharma Ki Dulhaniya Genre: Romantic drama Director: Shashank Khaitan Cast: Alia Bhatt, Varun Dhawan, Ashutosh Rana, Siddharth Shukla Rating: **1/2
Anandiben-patel

Gujarat CM welcomes budget

July-11-2014
Gujarat Chief Minister Anandiben Patel praised the first budget of Mr. Modi’s government, saying it was “all-inclusive and took care of the
bse--621x414

Nifty gains after Infosys earnings beat estimates

July-11-2014
Reuters Market Eye – The Nifty is 0.1 percent higher after Infosys (INFY.NS) April-June earnings beat estimates. India’s software stocks gain after