Partly Cloudy
32°CTue :Isolated Thunderstorms. High: 33 Low: 22

Mushroom compound boosts cancer drug

Mushroom compound boosts cancer drug

Washington: A compound from a wild, poisonous mushroom growing in the southwestern China`s forests, imparts greater punch to a cancer-busting drug, new research shows.

The compound, verticillin A, sensitizes cancer cells to TRAIL, a drug, causing cancer cells to self-destruct, said Kebin Liu, cancer immunologist at the Georgia Health Sciences University Cancer Centre and study co-author.

The compound pre-empts cancer cells from developing resistance to TRAIL (tumor necrosis factor-related apoptosis inducing ligand), reports the journal Cancer Research.

Drug resistance, intrinsic or acquired, is a major problem for cancer patients, accounting for more than 90 percent of treatment failures. “If we can make drugs work again, more people will survive,” Liu said, according to a Georgia Health statement.

“It looks as though most cancer cells have found a way to become resistant and evade its action,” said Wendy Bollag, cell physiologist and Liu`s counterpart in the study. Tenacious cancer cells are also naturally resistant to cell suicide, which is how TRAIL works.

In mice, they found verticillin A alone was adequate to kill cancer cells, but the required dose made the mice sick, a common problem with many cancer therapies.

However, when a lower dose was paired with TRAIL, it became a powerful, more tolerable recipe that killed previously resistant cells.

 

Top Stories

pomegranate-628x363-TS-160590221

Five capable wellbeing profits of consuming pomegranate!

September-02-2014
Pomegranate (natural name is Punica granatum) is a tasty foods grown from the ground, as well as high in sustenance. Rich in
abhi-ash_650_090214050713

Hubby Bachchan convinced Aishwarya Rai to take up Jazbaa

September-02-2014
Guess who was behind Aishwarya Rai’s decision to sign an action-thriller as her comeback vehicle? Yes, it was none other than her
TCS_Logo_Reuters

TCS, HCL Tech, Mahindra among dozen Indian cos in Forbes Asia’s Fab 50 rundown

September-02-2014
New Delhi: twelve Indian organizations figure in the 2014 Forbes Asia’s Fabulous 50 rundown of the region’s'best enormous traded on an open
bull-bear-market-4_slide

Sensex crosses 27000 imprint, Nifty hit new high on bringing down present record shortage; Cipla most astounding gainer

September-02-2014
The BSE Sensex today climbed by 151 focuses to surpass the 27,000-imprint shockingly and Nifty hit the record 8,100-level on purchasing by
224573-enough

Indeed schools and courts ought to have against inappropriate behavior manages set up

September-02-2014
The 20-part panel headed by resigned Justice Chandrashekhar Dharmadhikari has suggested adherence to the Vishakha rules, framed to handle lewd behavior at
social_welfare_16-9_0111_356

‘Love Jihad’: Improbability & test of change

September-02-2014
Leaving aside some narrative occurrences of between public affection and transformations to Islam coming about because of these contacts, the truth of