Partly Cloudy
32°CTue :Isolated Thunderstorms. High: 33 Low: 22

Turmeric can soothe gastric inflammation, ulcers

Turmeric can soothe gastric inflammation, ulcers

Kolkata: Turmeric at the optimum dose is highly effective in soothing gastric inflammation and ulceration, which could be the key to developing new drugs against such stomach disorders, say Indian scientists.

Turmeric, which belongs to the ginger family of plants, has been used as an alternative medicine since the last 3,000 years. It is also known to have antiseptic properties.

Curcumin is its major component responsible for the spice`s yellow colour and its therapeutic effects.

“It (curcumin) has been shown to be a good cure for gastric ailments like inflammation and ulceration. While its low doses are not effective, at high doses it might aggravate the situation. But we have come up with the optimum dose at which curcumin is therapeutic,” Snehasikta Swarnakar, senior scientist at Indian Institute of Chemical Biology (IICB)`s Drug Development Diagnostic and Biotechnology Division, who led the research, told IANS.

IICB is an institute under the Council of Scientific and Industrial Research (CSIR), India`s premier industrial R&D organisation.

Gastric ulceration and inflammation occur as a side effect to indiscriminate use of pain-killers (non-steroidal anti-inflammatory drugs or NSAIDs) and also due to stress.

Researcher conducted on rats helped in successfully evaluating the optimum dose. “For rats, the proper dose is around 50 mg per kg of their body weight, which is equivalent to 100 mg per kg of body weight in humans,” said Swarnakar.

The study, published in 2012 in the Anti-oxidants and Redox Signaling Journal, was also the first to shed light on the exact mechanism by which curcumin aids the healing process.

“This is the first study to reveal that the presence of curcumin in the system before or after ulcer development may promote formation of new blood vessels at the site of healing, and restore collagen fibres – the tissue that adds structural strength to body parts,” said co-researcher Nilanjana Maulik of the University of Connecticut School of Medicine, Farmington, US.

NSAIDs like indomethacin breaks up the blood vessel network in the stomach tissues and disrupts the collagen fibres – the tissue responsible for structural strength.

“Curcumin comes to the rescue by regulating the levels of two enzymes involved in the formation of new blood vessels, Swarnakar said.

One of the enzymes – MMP-2 – is a house-keeping enzyme that should be present in the system, and the other – MMP-9 – is inflammatory which is not required in the body.

“Curcumin increases the levels of MMP-2, while simultaneously lowering the MMP-9 level. This balance between the two enzymes is the key to its actions,” Swarnakar said.

 

Top Stories

pomegranate-628x363-TS-160590221

Five capable wellbeing profits of consuming pomegranate!

September-02-2014
Pomegranate (natural name is Punica granatum) is a tasty foods grown from the ground, as well as high in sustenance. Rich in
abhi-ash_650_090214050713

Hubby Bachchan convinced Aishwarya Rai to take up Jazbaa

September-02-2014
Guess who was behind Aishwarya Rai’s decision to sign an action-thriller as her comeback vehicle? Yes, it was none other than her
TCS_Logo_Reuters

TCS, HCL Tech, Mahindra among dozen Indian cos in Forbes Asia’s Fab 50 rundown

September-02-2014
New Delhi: twelve Indian organizations figure in the 2014 Forbes Asia’s Fabulous 50 rundown of the region’s'best enormous traded on an open
bull-bear-market-4_slide

Sensex crosses 27000 imprint, Nifty hit new high on bringing down present record shortage; Cipla most astounding gainer

September-02-2014
The BSE Sensex today climbed by 151 focuses to surpass the 27,000-imprint shockingly and Nifty hit the record 8,100-level on purchasing by
224573-enough

Indeed schools and courts ought to have against inappropriate behavior manages set up

September-02-2014
The 20-part panel headed by resigned Justice Chandrashekhar Dharmadhikari has suggested adherence to the Vishakha rules, framed to handle lewd behavior at
social_welfare_16-9_0111_356

‘Love Jihad’: Improbability & test of change

September-02-2014
Leaving aside some narrative occurrences of between public affection and transformations to Islam coming about because of these contacts, the truth of