Partly Cloudy
28°CTue :Thunderstorms Early. High: 30 Low: 16

Wild almond tree oil `may help combat obesity and diabetes`

Wild almond tree oil `may help combat obesity and diabetes`

Washington: Researchers, including one of Indian origin, have found that a future weapon in the battle against obesity and diabetes could come in the form of an oil derived from the seeds of wild almond trees.

According to researchers at Missouri University of Science and Technology, the key to the oil’s potential lies in its ability to affect certain microorganisms living in our bellies.

In the study, the researchers reported that adding sterculic oil to the diets of obese laboratory mice increased their sensitivity to insulin. This was due to the oil’s effect on three types of microorganisms that live in the guts of the mice.

As a result, the researchers saw a “statistically significant improvement in glucose tolerance and insulin sensitivity in the obese mice,” Shreya Ghosh, a Ph.D. student in environmental engineering at Missouri S and T, said.

The sterculic oil had no adverse affects on lean mice fed the same diet.

Sterculic oil is extracted from the seeds of the wild almond tree known as Sterculia foetida.

The research by Ghosh and her advisor, Dr. Daniel Oerther, builds upon previous studies conducted at the University of Missouri-Columbia. In those studies, sterculic oil was found to suppress the bodily enzyme stearoyl-CoA desaturase 1 (SCD1).

SCD1 is associated with insulin resistance, a condition that can lead to diabetes and obesity.

Other studies have shown that obese mice deficient in the hormone leptin have a different composition of “gut microbiota” than do lean mice.

Leptin helps regulate metabolism, and a deficiency of the hormone can contribute to obesity, says Oerther, the John and Susan Mathes Chair of Environmental Engineering at Missouri S and T.

In the Missouri S and T study, a diet supplemented by sterculic oil also correlated with lower levels of three types of gut microbiota – Actinobacteria, Bacilli and Erysipelotrichia – in the obese mice.

It isn’t clear, however, whether the lower levels of those microbiota led to the improvement of glucose tolerance and insulin sensitivity among the obese mice, Oerther says.

To perform her experiments, Ghosh studied 28 male mice – 14 of them obese and 14 normal, and each of them five weeks old at the beginning of the study.

She separated the mice into four groups and for nine weeks, fed a standard diet to one group of obese mice and one group of non-obese mice.

Over the same period, she fed the same diet, supplemented with 0.5 percent of sterculic oil, to one group of obese mice and one group of non-obese mice. Ghosh recorded the weights, food consumption and glucose levels of the mice during the nine-week period.

After the nine weeks, researchers conducted a DNA analysis of the gut microbiota at King Abdullah Institute of Science and Technology in Saudi Arabia.

The results confirmed correlations between the diet, improved glucose tolerance and groups of microbes. Even though the mice fed a diet with sterculic oil did not experience weight loss, both Ghosh and Oerther believe their findings could lead to new insights into controlling diabetes and weight gain.

 

Top Stories

Ford-Figo-Aspire-from-the-Indian-premiere

Ford Figo Aspire inside and highlights uncovered

May-05-2015
The run-up to the dispatch of the Ford Figo Aspire is by all accounts an incredible show. In the wake of teasing
kejriwal_650_042115051121_050515084328

Arvind Kejriwal says No free goes for AAP MLAs or priests for prominent events or concerts

May-05-2015
New Delhi: Chief Minister Arvind Kejriwal has coordinated all the administration authorities not to amuse the appeals of MLAs or pastors looking
14IN_LPN_GOLD_1843692f

Gold Price Surges by Rs 220 on Global Cues

May-05-2015
New Delhi: Gold snapped its three-day losing streak on Tuesday by surging Rs 220 to exchange at Rs 27,220 every 10 grams
s_1398760941_540x540

Salman Khan attempt at hit-and-run case: If blameworthy, he confronts 10 years in jail

May-05-2015
Bollywood star Salman Khan, known for his swelling biceps and off-cam hissy fits, confronts penitentiary this week if declared guilty shakily rolling
0

IPL 2015: Kolkata Knight Riders jog to triumph against Sunrisers Hyderabad

May-05-2015
KOLKATA: To guard 167, a group needs to get early achievements. Umesh Yadav did precisely that for Kolkata Knight Riders as he
narendra-modi

Modi to visit China from May 14

May-05-2015
Head administrator Narendra Modi will visit China one week from now, the Chinese Foreign Ministry said on Tuesday. Mr. Modi will be