Three years after her lover, Rick Usher, and her best friend, Maddy Usher, had suddenly disappeared from her life without explanation, Jill Masters receives a phone call with news of Maddy's death. Her last wish was for Jill to attend her funeral. Conflicted, Jill returns to the house of Usher, a remote New England enclave. Her love affair with Rick is rekindled as she learns he suffers from the same malady that robbed his twin sister, Maddy, of her sharp mind before taking her life. His affliction is manifested in a rare nerve condition, which renders him hyper-sensitive. Under the watchful eye of the caretaker, Nurse Thatcher, Jill appears to be haunted by the ghost of Maddy, and the secret of the house of Usher is exposed.